Trump is making his first trip abroad since winning the election as the first sitting president to visit the country since World War II.
The visit is set to be the first to the United Kingdom since a military operation to restore order in Brussels in 2016, which led to the resignation of the Belgian prime minister.
The president’s first stop in Brussels is on Wednesday for a NATO summit.
Trump will also meet with German Chancellor Angela Merkel and French President Emmanuel Macron in Berlin.
He will meet with the Japanese Prime Minister Shinzo Abe and Japanese Prime Secretary Shinzo Abe on Thursday and Friday.
Trump has yet to address the European Union, which is in crisis.
Trump said he would work with European allies and members of the European Commission to help the United Nations cope with the crisis.